Innovative Mesothelioma Treatment with Reqorsa® Gene Therapy

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News Summary

Genprex’s Reqorsa® Gene Therapy shows promise in treating mesothelioma, targeting the TUSC2 gene and addressing a critical need in cancer care.

Genprex Enters Exciting New Phase in Mesothelioma Treatment with Reqorsa® Gene Therapy

Genprex, Inc. (NASDAQ: GNPX), a clinical-stage gene therapy company based in Austin, Texas, is making waves in the fight against mesothelioma, a notoriously aggressive cancer with limited treatment options and a high mortality rate. With a market capitalization of $6.88 million, Genprex has recently signed an exclusive patent license agreement with NYU Langone Health, embracing a groundbreaking mission to develop its innovative drug candidate, Reqorsa® Gene Therapy (quaratusugene ozeplasmid).

Focus on Mesothelioma

Mesothelioma, primarily linked to asbestos exposure, presents devastating challenges. The Centers for Disease Control and Prevention reports that approximately 3,000 new cases are diagnosed each year in the United States, leading to about 2,500 deaths. In response to this urgent health crisis, Genprex aims to offer new hope with Reqorsa®, specifically targeting the tumor suppressor gene TUSC2, which is downregulated in around 84% of mesothelioma cases.

Cutting-Edge Technology

The exclusive license agreement not only grants Genprex patent exclusivity for treating mesothelioma but also highlights the innovative aspects of Reqorsa®. The therapy utilizes a unique formulation that includes the TUSC2 gene encapsulated in non-viral lipid-based nanoparticles, ensuring the therapy is intravenously administered while specifically targeting negatively charged cancer cells. This precision minimizes damage to normal tissues, enhancing patient safety.

Preclinical Triumphs

Preclinical studies have yielded promising results, showing that Reqorsa® significantly reduces cell proliferation and invasion in mesothelioma cell lines. Furthermore, it increases apoptosis, or programmed cell death, suggesting that re-expressing TUSC2 could be an effective therapeutic approach. Recent data presented at the 2024 EORTC-NCI-AACR Symposium showcased the tumor suppressive activity of TUSC2 delivered by Reqorsa®, elevating hopes for a breakthrough treatment.

A Strategic Move Forward

In the pursuit of advancing its mission, Genprex has established a Mesothelioma Clinical Advisory Board, comprising renowned researchers. This board will aid in refining the preclinical oncology program and ensuring that Genprex remains at the forefront of research developments.

Broadening Horizons

Not limiting its ambitions to mesothelioma, Genprex is also evaluating Reqorsa® in clinical trials for non-small cell lung cancer (NSCLC) and small cell lung cancer (SCLC). Both lung cancer trials have received Fast Track Designation from the FDA, underscoring the urgency and potential of these therapies. Furthermore, Genprex has announced exciting preclinical data focusing on KRASG12C mutant NSCLC, set to be presented at the 2025 American Association for Cancer Research Annual Meeting.

Staying Afloat Amidst Challenges

As Genprex presses on with its research and development efforts, the company encounters challenges, including a recent delisting warning from Nasdaq due to non-compliance with minimum bid price and stockholders’ equity requirements. The company is required to address the bid price issue by August 2025 and demonstrate a strong stockholders’ equity position of $2.5 million by May 2025.

Future Prospects

While facing regulatory hurdles, Genprex maintains a solid cash position relative to its debt, potentially supporting its development pipeline. In addition to mesothelioma therapies, Genprex is advancing its efforts in diabetes gene therapy, having entered into a collaboration focused on developing non-viral delivery systems in treating both Type 1 and Type 2 diabetes.

As Genprex moves forward, the company remains committed to overcoming compliance issues while continuing its quest for innovative treatment options in oncology. The road ahead is filled with promise as Reqorsa® Gene Therapy sparks hope for patients battling mesothelioma and beyond.